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KMID : 0380020080230020177
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Korean Journal of Biotechnology and Bioengineering
2008 Volume.23 No. 2 p.177 ~ p.182
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Inhibition effects of extracts and its solvent fractions isolated from Limonium tetragonum on growth of human cancer cells
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Kong Chang-Suk
Seo Young-Wan
Um Young-Ran
Lee Jung-Im
Kim You-Ah
Lee Jeom-Sook
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Abstract
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In this study, crude extracts of the halophyte Limonium tetragonum and their solvent fractions were evaluated on anticancer activity in AGS and HT-29 human cancer cells using MTT assay. Each of the crude extracts (MeOH and ) of Limonium tetragonum showed a significant inhibitory effect on the growth of human cancer cells. The combined crude extracts of MeOH and were partitioned between and water. The organic layer was further partitioned between 85% aq. MeOH and n-hexane, and then the aqueous layer was fractionated with n-BuOH and , successively. Growth inhibition effects of crude extracts and their solvent fractions from Limonium tetragonum increased in a dose-dependent manner. Among them, 85% aq. MeOH, n-hexane and n-BuOH fractions revealed very good inhibition effects on the growth of human cancer cells. These results suggest that we can isolate active compounds from Limonium tetragonum to show much more strong anticancer activity.
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KEYWORD
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Limonium tetragonum, anticancer effect, AGS human gastric cancer cells, HT-29 human colon cancer cells
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